Stanolone Dihydrotestosterone (DHT)

Name	Stanolone Dihydrotestosterone (DHT)
Synonyms	Androstanolone Cristerona MB DHT Dihydrotestosterone LG 152 NSC 10972 Neodrol Proteina Protona Stanaprol Stanorone
CAS NO	521-18-6
MF	C19H30O2
MW	290.44
EINECS	208-307-3
Product Categories	API; Intermediates & Fine Chemicals; Pharmaceuticals; Steroid and Hormone; Steroids
Mol File	521-18-6.mol

Stanolone Chemical Properties
Melting point	178-183 °C
alpha	27 º
Boiling point	372.52°C (rough estimate)
density	1.0320 (rough estimate)
refractive index	1.4709 (estimate)
Fp	9℃
storage temp	Controlled Substance, -20°C Freezer
form	neat
pka	15.08±0.60(Predicted)
Water Solubility	344.3g/L(temperature not stated)
Merck	13,8872
BRN	2056371
InChIKey	NVKAWKQGWWIWPM-ABEVXSGRSA-N
CAS DataBase Reference	521-18-6(CAS DataBase Reference)
NIST Chemistry Reference	Stanolone(521-18-6)
EPA Substance Registry System	Androstan-3-one, 17-hydroxy-, (5.alpha.,17.beta.)- (521-18-6)

Safety Information
Hazard Codes	Xn,T,F
Risk Statements	61-40-39/23/24/25-23/24/25-11
Safety Statements	53-36/37/39-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	BV8052000

Stanolone Usage And Synthesis
Description	Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles.It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy
Chemical Properties	White Crystalline Solid
Originator	Neodrol,Pfizer,US,1953
Uses	Anabolic steroid. Controlled substance
Definition	ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with alpha- configuration at position 5
Manufacturing Process	A solution of 1.0 g of 3,17-androstandione in 50 ml of methanol and containing 1 g of selenium dioxide, was allowed to remain in an ice-chest overnight. The formed 3,3-dimethoxyandrostan-17-one was not separated. 1 g of solid potassium hydroxide and 2.5 g of sodium borohydride in 2.5 ml of water were added and the mixture allowed to react at room temperature for 24 hours. The solution was then poured into a large excess of water, extracted with methylene chloride, the organic layer dried and evaporated to a residue. The residue was dissolved in ether, and a small amount of selenium removed by filtration. The ether was boiled off and the organic material dissolved in 100 ml of boiling acetone. 25 ml of diluted hydrochloric acid were added, the solution boiled for 5 minutes and then allowed to cool. Upon crystallization, 0.85 g of androstan-17β-ol-3-one was obtained, melting point 175°C to 178°C.
Therapeutic Function	Androgen
References	https://en.wikipedia.org/wiki/Dihydrotestosterone#Medical_use Swerdloff, R. S., and C. Wang. "Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent."Baillieres Clin Endocrinol Metab 12.3(1998):501.