| Name | Anecortave Acetate |
|---|---|
| Synonyms | H6; Al 3789; Retaane; NSC 15475; NSC 24345; Anecortave; Anacorta acetate; anecortave acetate; ANECORTAVE ACETATE (200 MG)F0E2980.997MG/MG(AI); Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate |
| CAS NO | 7753-60-8 |
| CBNumber | CB5501441 |
| Molecular Formula | C23H29O6- |
| MOL File | 7753-60-8.mol |
| Molecular Weight | 401.47276 |
| Anecortave Acetate Chemical Properties | |
|---|---|
| Melting point | 230-234°C |
| alpha | D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3) |
| density | 1.23±0.1 g/cm3(Predicted) |
| pka | 12.47±0.60(Predicted) |
| storage temp | -20?C Freezer |
| Anecortave Acetate Usage And Synthesis | |
|---|---|
| Chemical Properties | Off-White Solid |
| Uses | As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration. |
| Enzyme inhibitor | This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model. |
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