Hydrocortisone acetate

Name	Hydrocortisone acetate
Synonyms	Hc45; Mysone; Cordes; Cortef; Cortes; nsc741; Efcolin; Epifoam; Lenirit; NSC 741 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-ACETATE 17-ALPHA-HYDROXYCORTICOSTERONE ACETATE 17-HYDROXYCORTICOSTERONE 21-ACETATE 17-HYDROXYCORTICOSTERONE ACETATE 21-acetoxy-4-pregnene-11b,17a-diol-3,20-dione 21-ACETOXY-4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETOXY-4-PREGNENE-11BETA,17ALPHA-DIOL-3,20-DIONE 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 4-PREGNEN-11BETA,17ALPHA,21-TETROL-3,20-DIONE 21-ACETATE 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE ACETIC ACID 2-((8S,9S,10R,11S,13S,14S,17R)-11,17-DIHYDROXY-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER CORTISOL 21-ACETATE CORTISOL ACETATE DELTA4-PREGNEN-11BETA,17ALPHA-21-TRIOL-3,20-DIONE-ACETATE HYDROCORTISONE 21-ACETATE HYDROCORTISONE ACETATE HYDROCORTISONI ACETAS HYDROCORTONE ACETATE LANACORT (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
CAS NO	50-03-3
CBNumber	CB7196805
Molecular Formula	C23H32O6
Formula Weight	404.5

Hydrocortisone acetate Chemical Properties
Melting point	223 °C (dec.)(lit.)
alpha	D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
density	d420 1.289
Boiling poin	446.1°C (rough estimate)
storage temp	0-6°C
refractive index	1.4593 (estimate)
Fp	223°C
solubility	Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
Stability	Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
NIST Chemistry Reference	Hydrocortisone acetate(50-03-3)
Water Solubility	Insoluble in water
Decomposition	223 ºC
Merck	14,4787
BRN	2066841
CAS DataBase Reference	50-03-3(CAS DataBase Reference)

Safety Information
Safety Statements	36/37-45-53
WGK Germany	3
RTECS	GM8960000
HS Code	29372100
Hazard Codes	Xn,
Risk Statements	63-10-45
Toxicity	LD50 intraperitoneal in mouse: 2300mg/kg

Hydrocortisone acetate Usage And Synthesis
Adrenocorticotropic hormone drugs	Hydrocortisone acetate Usage And Synthesis Adrenocorticotropic hormone drugs Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone. Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.
Indications	For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis.Figure 1 the chemical structure formula of tetra-fluoroethane.
Contraindications	1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited. 2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited. The above information is edited by the chemicalbook of KuiMing.
Adverse Reactions	Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.
Precautions	1. Not long-term, large-scale use. 2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.
Chemical Property	White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.
Uses	Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect
Production methods	Hydrocortisone and acetic anhydride in pyridine esterification.
Chemical Properties	white powder
Uses	Glucocorticoid
Brand name	Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck).
Purification Methods	The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]