| Name | PrednisoloneAcetate |
|---|---|
| Synonyms | 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE 1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE 1-DEHYDROCORTISOL 21-ACETATE 21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE DELTACORTENOLO HYDROCORTIDELT INFLANEFRAN METACORTANDROLONE ACETATE PREDNISOLONE 21-ACETATE PREDNISOLONE ACETATE PRICORTIN (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione 11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione |
| CAS NO | 52-21-1 |
| [EINECS(EC#)] | 200-134-1 |
| MDL Number | MFCD00037710 |
| Molecular Weight | 402.48 |
| Molecular Formula | C23H30O6 |
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| Prednisolone-21-acetate Chemical Properties | |
|---|---|
| Melting point | 240-244 °C |
| alpha | D25 +116° (dioxane) |
| density | 1.28±0.1 g/cm3(Predicted) |
| Boiling poin | 579.8±50.0 °C(Predicted) |
| storage temp | 2-8°C |
| refractive index | 112 ° (C=1, Dioxane) |
| form | neat |
| solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. |
| Water Solubility | 11.6mg/L(25 ºC) |
| BRN | 3111798 |
| Merck | 7721 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| NIST Chemistry Reference | 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1) |
| CAS DataBase Reference | 52-21-1(CAS DataBase Reference) |
| Safety Information | |
|---|---|
| Hazard Codes | T,C,F |
| Risk Statements | 25-34-11 |
| Safety Statements | 45-36/37/39-26-16 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TU4152500 |
| HS Code | 29372900 |
| Prednisolone-21-acetate Usage And Synthesis | |
|---|---|
| Chemical Properties | White or almost white, crystalline powder. |
| Originator | Sterane, Phipharmex ,US ,1955 |
| Uses | Synthetic corticosteroid; metabolically interconvertible with prednisone |
| Uses | glucocorticoid |
| Manufacturing Process | To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C. |
| Brand name | Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer) |
| Therapeutic Function | Glucocorticoid |
| Purification Methods | Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.] |
| Package method |
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