| Name | Canrenone |
|---|---|
| Synonyms | sc9376 11614r.p phanurane CANRENONE ALDADIENE NSC 261713 CANRENONE-D4 Canrenone, >=97% Canrenone98.5%Min spirolactonesc14266 Journal of risperidone CANRENOIC ACID GAMMA LACTONE Spironolactone EP Impurity F Eplerenone IMpurity - Canrenone Spironolactone Related CoMpound A CANRENONE[SPIRONOLACTONE INTERMEDIATE] 4,6-ANDROSTEN-17-ALPHA-YL-PROPIONIOACID-R-LACTONE 17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone 17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone 17a-2-Carboxyethyl-17-hydroxyandrosta-4,6-dien-3-one Lactone 4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE 17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone 17a-(2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one Lactone (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylicacidγ-lactone (7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone PREGNA-4,6-DIENE-17-BETA-0L-3-ONE-21-CARBOXYLIC ACID-GAMMA LACTONE (17R)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone (17R)-3-Oxo-17-hydroxypregna-4,6-diene-21-carboxylic acid γ-lactone (7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid g-Lactone ((7 )-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone) 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)- pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph 17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid Canrenone 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone Spironolactone Related Compound A (100 mg) (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (AS) (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione |
| CAS NO | 976-71-6 |
| MDL Number | MFCD08064191 |
| EINECS(EC# | 213-554-5 |
| Molecular Weight | 340.46 |
| Molecular Formula | C22H28O3 |
| Canrenone Chemical Properties | |
|---|---|
| Melting point | 158-1600C |
| alpha | D +24.5° (chloroform) |
| density | 1.1236 (rough estimate) |
| Boiling poin | 416.25°C (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp | Store at RT |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +17 to +24°, c = 1 in chloroform-d |
| Water Solubility | 272.4ug/L(25 ºC) |
| CAS DataBase Reference | 976-71-6 |
| NIST Chemistry Reference | Canrenone(976-71-6) |
| Safety Information | |
|---|---|
| Hazard Codes | Xn,N |
| Risk Statements | 40-51/53 |
| Safety Statements | 36/37-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29329990 |
| Canrenone Usage And Synthesis | |
|---|---|
| Chemical Properties | Pale yellow to pale Green Solid |
| Uses | Aldosterone antagonist. Diuretic |
| Uses | antiinflammatory, glucocorticoid |
| Brand name | Luvion |
| orld Health Organization | (WHO) Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone. |
| Biological Activity | Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ). |
| Canrenone Preparation Products And Raw materials | |
|---|---|
| Raw materials | Iodomethane-->Potassium Propionate-->Androstenediol |
| Package method |
|---|
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