| Name | Fluocinonide |
|---|---|
| Synonyms | Cortalar; Gelisyn; Lidemol; Fluocinonide (100 mg); Fluocinonide(Vanos); (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Flucetonide; Vanos |
| CAS NO | 356-12-7 |
| EINECS | 206-597-6 |
| Molecular Weight | 494.52 |
| Molecular Formula | C26H32F2O7 |
| Product Categories | Steroids; LIDEX; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals |
| Mol File | 356-12-7.mol |
Fluocinonide Chemical Properties | |
|---|---|
| Melting point | 309 °C |
| density | 1.2001 (estimate) |
| Boiling point | 235°C (rough estimate) |
| storage temp | Refrigerator |
| solubility | DMSO: ≥19mg/mL |
| form | powder |
| alpha | D +83° (chloroform) |
| pka | 12.77±0.70(Predicted) |
| Water Solubility | 0.53mg/L(25 ºC) |
| color | white to tan |
| optical activity | [α]/D +75 to +90°, c = 1 in dichloromethane |
| InChIKey | WJOHZNCJWYWUJD-IUGZLZTKSA-N |
| Safety Information | |
|---|---|
| Hazard Codes | T+ |
| Risk Statements | 28-63 |
| Safety Statements | 22-25-28-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | TU3831000 |
| HazardClass | 6.1(a) |
| HS Code | 2937220000 |
| PackingGroup | I |
| Fluocinonide Usage And Synthesis | |
|---|---|
| Chemical Properties | White Solid |
| Originator | Topsyn ,Recordati,Italy,1970 |
| Uses | Glucocorticoid; anti-inflammatory |
| Uses | Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid. |
| Indications | Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid. |
| Manufacturing Process | To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room temperature for 3 hours. During this period the crystals gradually dissolve and the clear solution is neutralized with dilute bicarbonate and the acetone removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95% alcohol to give the pure acetonide. A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine and 1 ml of acetic anhydride is allowed to stand at room temperature for 18 hours. Removal of the reagents in vacuo gives a crystalline residue which after crystallization from acetone-hexane gives the pure 16α,17α- isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described in US Patent 3,197,469. |
| Brand name | Lidex (Medicis); Vanos (Medicis). |
| Therapeutic Function | Antiinflammatory, Glucocorticoid |
| Fluocinonide Preparation Products And Raw materials | |
|---|---|
| Raw materials |
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| Package method |
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FAQ
MOQ: 100 gram
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