| Name | Anecortave Acetate |
|---|---|
| Synonyms | [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; 17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate; 17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate; anecortave acetate; Anacorta acetate; Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate; 17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIENE-21-YL ACETATE; 21-Acetoxy-17-hydroxypregna-4,9(11)-diene-3,20-dione |
| CAS NO | 7753-60-8 |
| EINECS | 231-812-5 |
| Molecular Weight | 401.47276 |
| Molecular Formula | C23H29O6- |
| Product Categories | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
| Mol File | 7753-60-8.mol |
Anecortave Acetate Chemical Properties | |
|---|---|
| Melting point | 230-234°C |
| Boiling point | 551.8±50.0 °C(Predicted) |
| density | 1.23±0.1 g/cm3(Predicted) |
| alpha | D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3). |
| pka | 12.47±0.60(Predicted) |
| storage temp | -20?C Freezer |
| Anecortave Acetate Usage And Synthesis | |
|---|---|
| Chemical Properties | Off-White Solid |
| Uses | As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration. |
| Enzyme inhibitor | This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model. |
| Package method |
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